Inbreeding coefficient population genetics pdf

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the aims of this study are (i) to fill the gap between the two classical approaches, by showing that effects of finite population size can be expressed in terms of inbreeding coefficients ( f ), just as in the case of systematic inbreeding, and by reevaluating the role of physical linkage in this context; and (ii) to relax the restrictive … the properties of the population, relative to those in a random-bred stock. It waa for this reason that it waa suggested that it would be the most suitable inbreeding coefficient (Wright, 1922a). THE INBREEDING COEFFICIENT F The rate of decreaae of heterozygosis in systems of mating more complicated than self-fertilization Estimates of the two parameters from pedigrees (FPEDand ΦPED) were computed using the RelaX2 program. Values of the two parameters estimated from genomic and genealogical data were mostly consistent, in particular for the highly inbred animals (e.g. inbreeding coefficient F>0.0625) and pairs of closely related animals (e.g. the full- or half-sibs). This figure compares distributions of coalescence times of different pairs of genes, used to define inbreeding coefficients. Three different cases are considered. ( a) Selfed individuals in a ABSTRACT A theory is given that allows inbreeding coefficients to be calculated exactly for populations with overlapping generations. Emphasis is placed on providing equations well suited for computer iteration. Both monoecious and dioecious populations are considered and family size is not restricted to being Poisson. We find extremely inbred dogs in each breed except the greyhound and estimate an inbreeding effective population size between 40 and 80 for all but 2 breeds. For all but 3 breeds, >90% of unique genetic variants are lost over six generations, indicating a dramatic effect of breeding patterns on genetic diversity. Summary - An algorithm for computing inbreeding coefficients in large populations is presented. It is especially useful in large populations because of the small size the memory required, which is linear with population size, and its speed, if the number of generations involved is not too large, ie not larger than about 12. The method compared Download PDF. Article; Open Access; Figure 4 shows that within-population inbreeding coefficients sampling variances and use in estimation of inbreeding coefficients. Genetics 107:703-718. Tier (1990) presents a fast method for the calculation of inbreeding coefficients. ments in the additive genetic relationship matrix A are required and then calculates The memory required is a small proportion of NZ: about 0.9%. ulations, the physical memory of the computer is still likely to be too small and use A fast algorithm for computing inbreeding coefficients in large populations in which a list of ancestors for each animal is required is modified for more quick calculation and requires much less computer time and less memory than the original and another typical algorithms. 4 PDF Inbreeding coefficient Inbreeding and self-fertilization Genotypes m